NCT06758843

Comparing Relative Peripheral Refraction on Myopia Progression

A Prospective, Controlled, Parallel Trial of Comparing Relative Peripheral Refraction Between Parameters Before and After Myopia Progression with Multispectral Refraction Topography

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 6,000 (actual)
• Sponsor: Fuzhou Southeast Institute of Visual Ophthalmology · Academic / Other
• Sex: All
• Age: 7 Years – 17 Years
• Healthy volunteers: Accepted

Summary

The investigators will test our hypothesis that parameters on peripheral defocus can regulate eye growth: For instance, the relative peripheral refraction measured by Multispectral Refraction Topography (MRT) would be significant different between two groups: fast speed and slow speed of axial length elongation (myopia progression) for 1 year with 2-3 follow-ups. The goal of this observation study is to confirm the value of MRT in clinic. Could it predict myopia progression or not? By the parameters on relative peripheral refraction in children myopia, could include any of the following: both genders, 7\~17 years age groups, including healthy volunteers. The main question it aims to answer is: Is any of relative peripheral refraction parameters measured by MRT could guide the clinics for predict myopia progression? Which parameters from MRT could predict the myopia fast progression at baseline ? There is a comparison between groups. Researchers will compare fast myopia progression group versus slow myopia progression group to see if any parameters differs at baseline. Participants will be asked to the collection methods (such as spectacles, orhtokeratology, contact lens) and interventions; And each participant would be followed up for at least 2 times in one year to test the axial length and refractive error as well as parameters with MRT.

Detailed description

Visual signals from the surrounding retina play a crucial role in the process of emmetropization in the peripheral area of retina and may be a key factor in the development of myopia. Peripheral defocus can regulate eye growth, particularly peripheral hyperopic defocus, which is a high-risk factor for promoting eye growth and the onset and progression of myopia. In recent years, with the establishment of new experimental animal models and the emergence of new detection technologies, the relationship between peripheral defocus and myopia has received increasing attention. The axial length of the eye is the most important indicator for assessing myopia progression. About 7000 students from Ningbo would be follow-up for the MRT and their myopia progression for at least 1 year.

Conditions

• Myopia

Interventions

Type	Name	Description
OTHER	measure the axial length, visual acuity, and refraction at follow-up of 6- and 12-month	the intervention is follow-up with parameters to measure and data to record

Timeline

• Start date: 2022-07-23
• Primary completion: 2024-12-29
• Completion: 2024-12-29
• First posted: 2025-01-06
• Last updated: 2025-01-07

Locations

1 site across 1 country: China