NCT06757374

First Trimester Resistin Levels in HG

Evaluation of First-Trimester Maternal Serum Resistin in Hyperemesis Gravidarum

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 210 (actual)
• Sponsor: Dr. Lutfi Kirdar Kartal Training and Research Hospital · Other Government
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This cross-sectional case-control study was conducted in Tuzla State Hospital Obstetrics Clinic in Turkey. The study evaluated 400 pregnant women during their first trimester of pregnancy. Many pregnant women (50-90%) experience nausea and vomiting during their first trimester; however, some patients have a disease called "hyperemesis gravidarum" (HG) characterized by very severe nausea and vomiting that may require hospitalization. resistin" is a peptide which is secreted primarily by human adipocytes and mononuclear cells. Evidence suggests that resistin increases plasma glucose concentration, reduces glucose intake by adipocytes, and promotes insulin resistance. Considering the HG effect on endocrinologic and metabolic complications, we hypothesized that resistin levels in maternal serum may change in the presence of HG; therefore, the aim of the present study was to evaluate these resistin levels during the first trimester and their correlation with HG severity.

Conditions

• Hyperemesis Gravidarum - Severe
• Resistin
• Gestational Diabetes Mellitus (GDM)

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Resistin	Considering the HG effect on endocrinologic and metabolic complications, resistin levels in maternal serum may change in the presence of HG severity

Timeline

• Start date: 2022-12-15
• Primary completion: 2023-03-15
• Completion: 2023-06-01
• First posted: 2025-01-03
• Last updated: 2025-01-03

Locations

1 site across 1 country: Turkey (Türkiye)