NCT06756984

Long-Term Outcomes of Different Surgical Techniques for Sacral Tarlov Cysts: A Prospective Cohort Study

A Prospective Cohort Study on the Long-Term Outcomes and Prognostic Factors of Different Surgical Techniques for the Treatment of Sacral Tarlov Cysts

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Beijing Jishuitan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Brief Summary The goal of this observational study is to evaluate the long-term outcomes of different surgical techniques for sacral Tarlov cysts in adult patients aged 18-75 years diagnosed with symptomatic sacral Tarlov cysts. The main questions it aims to answer are: * Does one surgical technique result in better pain relief (measured by VAS score) and functional recovery (measured by JOA score) compared to others? * How do different surgical techniques impact the long-term recurrence rate and complication rate? Researchers will compare three surgical techniques: 1. Partial cyst wall resection with nerve root sleeve plasty. 2. Partial cyst wall resection with nerve root sleeve reinforcement and reconstruction. 3. Autologous fat/muscle with fibrin glue microscopic cyst filling. Participants will: * Undergo one of the three surgical procedures based on clinical indications. * Complete preoperative and postoperative assessments, including pain and functional scoring, as well as MRI evaluations at baseline and during follow-up. * Participate in a follow-up program for up to 2 years to monitor outcomes and recurrence.

Conditions

• Sacral Tarlov Cysts
• Symptomatic Sacral Cysts
• Chronic Pain Related to Sacral Cysts
• Neurological Dysfunction Associated With Tarlov Cysts

Interventions

Type	Name	Description
PROCEDURE	Partial Cyst Wall Resection with Nerve Root Sleeve Plasty	Surgical technique involving partial removal of the cyst wall to decompress the nerve root, followed by plasty of the nerve root sleeve to restore nerve function and prevent recurrence.
PROCEDURE	Partial Cyst Wall Resection with Nerve Root Sleeve Reinforcement and Reconstruction:	Advanced surgical technique combining partial cyst wall removal with additional reinforcement and reconstruction of the nerve root sleeve to provide enhanced support and reduce the risk of cyst recurrence.
PROCEDURE	Autologous Fat/Muscle with Fibrin Glue Microscopic Cyst Filling	Minimally invasive surgical technique where autologous fat or muscle tissue is used to fill the cyst cavity, and fibrin glue is applied to seal the defect, aiming to obliterate the cyst and prevent cerebrospinal fluid leakage.

Timeline

• Start date: 2025-05-13
• Primary completion: 2026-06-30
• Completion: 2026-12-31
• First posted: 2025-01-03
• Last updated: 2025-05-13