NCT06753630

Polydeoxyribonucleotide for Elbow Lateral Epicondylitis

Does Combined Polydeoxyribonucleotide Improve the Outcome of Extensor Muscle Strengthening Exercise with Extracorporeal Shockwave Therapy for Lateral Epicondylitis of Elbow?: a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Chuncheon Sacred Heart Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to investigate the synergistic effect of polydeoxyribonucleotide (PDRN) on extensor muscle strengthening exercise (EMSE) combined with extracorporeal shockwave therapy (ESWT) for treating lateral epicondylitis (LE) of the elbow in adults aged 18 to 65 years. The main questions it aims to answer are: Does the addition of PDRN improve pain reduction as measured by the Visual Analog Scale (VAS)? Does the addition of PDRN enhance functional outcomes such as the Mayo Elbow Performance Score (MEPS) and Hand Grip Strength Index (HGSI)? Researchers will compare two groups to see if PDRN provides additional benefits: Group 1: EMSE + ESWT + saline injection Group 2: EMSE + ESWT + PDRN injection Participants will: Perform extensor muscle strengthening exercises Receive extracorporeal shockwave therapy Receive either a saline injection or a PDRN injection at the first outpatient department visit Attend follow-up visits at 6 and 12 weeks for assessments

Conditions

• Lateral Epicondylitis
• Extracorporeal Shockwave Therapy
• Muscle Strengthening

Interventions

Type	Name	Description
BEHAVIORAL	Extensor Muscle Strengthening Exercise	A series of exercises aimed at strengthening the extensor muscles of the forearm to alleviate symptoms of lateral epicondylitis.
PROCEDURE	Extracorporeal Shockwave Therapy	A non-invasive procedure that uses shockwaves to promote healing and reduce pain in the affected area.
DRUG	Saline injection (Octreotide LAR placebo)	A 3mL injection of saline solution used as a placebo in the study.
DRUG	Polydeoxyribonucleotide Injection	A 3mL injection of polydeoxyribonucleotide (5.625mg/3mL) used to enhance the healing process and improve outcomes in lateral epicondylitis treatment.

Timeline

• Start date: 2014-11-20
• Primary completion: 2015-11-30
• Completion: 2016-11-30
• First posted: 2024-12-31
• Last updated: 2024-12-31

Locations

1 site across 1 country: South Korea