NCT06751030

Community, Home-based Education, Screening Services Strategy to Increase Cervical Cancer Control Access for HIV-Positive Women in Nigeria

Community, Home-based Education, Screening Services (CHESS) Strategy to Increase Cervical Cancer Control Access for HIV-Positive Women in Nigeria

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,500 (estimated)
• Sponsor: Emory University · Academic / Other
• Sex: Female
• Age: 25 Years – 50 Years
• Healthy volunteers: —

Summary

The goal of this observational study is to focus on adapting and implementing a program to promote HPV and cervical cancer (CC) screening and follow-up treatment for HIV-positive women, with three specific aims: * Adaptation: Use stakeholder deliberation to tailor the successful MoMent program for this population. * Implementation and Assessment: Deploy the adapted MoMent program and evaluate its reach, effectiveness, adoption, and fidelity. * Evaluation: Conduct a post-implementation process evaluation to identify barriers and facilitators to the program's maintenance and sustainability.

Detailed description

Despite the increased risk of cervical cancer (CC) among women living with HIV (WLWH), access to CC screening in Nigeria remains limited. While advances in prevention programs and antiretroviral therapy have reduced other AIDS-associated malignancies, CC risk in WLWH persists. This study aims to leverage Nigeria's existing HIV treatment infrastructure to integrate home-based CC (HCC) screening for WLWH. The approach involves adapting the MoMent (MOther MENTor) peer-based HIV support program to include HCC screening and evaluating its implementation and sustainability using the Consolidated Framework for Implementation Research (CFIR) and RE-AIM frameworks. The study has three key aims: * Adapting the MoMent program to promote home-based HPV screening and follow-up treatment through stakeholder deliberation. * Implementing and assessing the program's reach, effectiveness, adoption, and fidelity with a sample of 1,500 WLWH. * Conducting a post-implementation evaluation to identify barriers and enablers for program maintenance and scalability. Stakeholder input, including perspectives from WLWH, peer counselors, clinical managers, and policymakers, will guide the program's design and execution. By integrating stakeholder insights and addressing systemic challenges, the study aims to advance CC control in Nigeria and provide a scalable model for implementing cancer control strategies for people living with HIV in low- and middle-income countries globally.

Conditions

• HIV
• Cervical Cancer

Interventions

Type	Name	Description
BEHAVIORAL	The Mother Mentor program	The MOther MENTor (MoMent) program in Nigeria pairs trained treatment-experienced Women living with HIV (WLWH), known as Mentor Mothers (MMs), with new mothers who are newly diagnosed with HIV to improve access to and retention in HIV care
DIAGNOSTIC_TEST	GeneXpert HPV test	A cervical cancer screening tool.

Timeline

• Start date: 2024-12-03
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2024-12-27
• Last updated: 2025-08-06

Locations

3 sites across 1 country: Nigeria