NCT06750497

Forearm Immobilization in T2D

The Impact of Short-term Forearm Immobilization on Forearm Muscle Glucose and Amino Acid Metabolism of Volunteers With or Without Type 2 Diabetes

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (estimated)
• Sponsor: Wageningen University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The aim of the present study is to assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics in individuals with T2D compared with a control group with normoglycaemia.

Detailed description

Participants with and without T2D will undergo 2 days of forearm immobilization as a model of local physical inactivity. Before, throughout, and after immobilization arteriovenous forearm balance measurements will be combined with a stable isotope tracer infusion to measure muscle glucose uptake and amino acid balance, uptake, and efflux.

Conditions

• Healthy
• Type 2 Diabetes

Interventions

Type	Name	Description
BEHAVIORAL	Forearm immobilization	Two days of forearm immobilization

Timeline

• Start date: 2024-11-21
• Primary completion: 2026-04-30
• Completion: 2026-04-30
• First posted: 2024-12-27
• Last updated: 2025-07-15

Locations

1 site across 1 country: Netherlands