NCT06748807

Physiological Effects of APRVplus and TCAV in ARDS

Physiological Effects of Early Pathophysiology-driven Airway Pressure Release Ventilation (APRVplus) and Time-Controlled Adaptive Ventilation (TCAV) in Acute Respiratory Distress Syndrome (ARDS): a Randomized Crossover Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: West China Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In previous studies, airway pressure release ventilation (APRV) has been proven to be an important respiratory support method for ARDS patients, and various APRV ventilation strategies have been proposed. This study aims to compare the physiological effects of two types of APRV ventilation strategy, Early Pathophysiology-driven APRV (APRVplus) and Time-Controlled Adaptive Ventilation (TCAV), through randomized crossover trials, providing evidence for clinical application and further research on APRV.

Conditions

• ARDS (Acute Respiratory Distress Syndrome)

Interventions

Type	Name	Description
PROCEDURE	APRVplus	Early Pathophysiology-driven Airway Pressure Release Ventilation (APRVplus)
PROCEDURE	TCAV	Time-Controlled Adaptive Ventilation (TCAV)

Timeline

• Start date: 2023-12-15
• Primary completion: 2024-12-15
• Completion: 2024-12-15
• First posted: 2024-12-27
• Last updated: 2024-12-27

Locations

1 site across 1 country: China