NCT06748430

Effects on Glycemia and Insulinemia of Different Grape Varieties

Assessment of the Effect of Different Varieties of Grapes on Postprandial Glycemia and Insulinemia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Clinica Universidad de Navarra, Universidad de Navarra · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The goal of this intervention study is to examine the glucose increase in blood, during 2 hours after consuming different varieties of grapes, in men and women with normal or excess body weight. The main question it aims to answer is: can a variety of red grape reduce the glucose curve compared to a reference variety? Participants will have to attend the Center for nutrition research facilities in three occasions, fasted for at least 8 hours. Once there, they will be measured and monitored. A canula will be inserted and once they finish eating 300g of grapes, blood extractions will be performed at minutes 15, 30, 60, 90 and 120.

Detailed description

The main purpose of this study is to evaluate how the glucose and insulin curves develop after consuming different grapes varieties. Still, we also want to evaluate how the serum metabolome changes with the three varieties after 120 minutes. Therefore, a metabolomic study will be done in samples of volunteers at this time point. The intervention is longitudinal and in three arms (one per variety). Due to the harvest of the different varieties, it cannot be crossover, but each subject will consume the three varieties. At each visit, the subjects will undergo the same schedule: * Arrival in a fasting state of at least 8 hours. * Insertion of cannula and extraction of fasting samples * Consumption of approximately 300 g of grapes (50 g of Carbohydrates). * Extraction of blood samples at 15, 30, 60, 90 and 120 minutes.

Conditions

• Healthy
• Glycaemic Response Measurements

Interventions

Type	Name	Description
OTHER	Grape variety control	Reference grape variety
OTHER	Grape variety 1	First grape variety to evaluate
OTHER	Grape variety 2	Second grape variety to evaluate

Timeline

• Start date: 2024-06-25
• Primary completion: 2024-11-29
• Completion: 2024-11-29
• First posted: 2024-12-27
• Last updated: 2024-12-27

Locations

1 site across 1 country: Spain