NCT06748144

IO Vancomycin Spine

Intraosseous vs. Intravenous Vancomycin Administration in Spine Surgery

• Status: Not Yet Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: The Methodist Hospital Research Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this research is to learn if injecting the antibiotic vancomycin directly into the bone marrow (intraosseous) or IO) during a lumbar (spinal) fusion surgery, is as effective or better than the standard method of giving it vancomycin through a vein (intravenous) or IV) during lumbar fusion surgery.

Conditions

• Lumbar Fusion Surgery

Interventions

Type	Name	Description
DRUG	Intraosseous Vancomycin	The intervention is specific to the method of administration that will be used when giving the dose of antibiotic vancomycin which is done to prevent infection following surgery.
DRUG	Intravenous Vancomycin	This is the standard method of giving the antibiotic vancomycin to patients undergoing surgery across many specialties in order to prevent infection.

Timeline

• Start date: 2026-05-01
• Primary completion: 2027-04-01
• Completion: 2030-04-01
• First posted: 2024-12-27
• Last updated: 2026-03-25

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study