NCT06746805

The Effect of Acute Ketone Monoester Supplementation on Glucose Oxidation During Exercise

The Effect of Acute Ketone Monoester Supplementation on Glucose Oxidation During Exercise Performed With High Rates of Carbohydrate Ingestion in Trained Cyclists

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (estimated)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine the effect of exogenous ketone body supplementation on carbohydrate metabolism during exercise. In a randomized, crossover, and double-blind study, 20 endurance trained adult males and females aged 18-50 years, will ingest carbohydrates with either a ketone monoester supplement before and throughout a 3-hour exercise session or carbohydrates with a flavour-matched ketone-free placebo. The main aim of this study is to compare the exogenous carbohydrate oxidation rates during exercise between the ketone monoester and placebo conditions.

Conditions

• Exercise Metabolism

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	CHO+KETONE	Sports drink containing glucose and ketone mono-esters
DIETARY_SUPPLEMENT	CHO+PLACEBO	Sports drink containing glucose and placebo

Timeline

• Start date: 2024-03-04
• Primary completion: 2025-09-30
• Completion: 2025-09-30
• First posted: 2024-12-24
• Last updated: 2025-09-24

Locations

1 site across 1 country: Netherlands