NCT06744816

Exploring the Benefit of Topical Capsaicin in Treating Pain From Chemo-induced Peripheral Neuropathy: a Longitudinal Single Center Pilot Study

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To learn if topical capsaicin can help relieve pain from CIPN and improve gait (the pattern of walking) in patients.

Detailed description

Primary Objectives • To assess changes in Gait (specifically looking at velocity) before and after use of topical capsaicin. Secondary Objectives * To assess Pain intensity numerical rating scale (NRS) scores in chemotherapy induced peripheral neuropathy (CIPN) participants before and after use of capsaicin 8% topical patch. * To assess changes in quantitative sensory testing (QST) before and after use of topical capsaicin. * To assess skin punch biopsy to compare the integrity of epidermal nerve fibers and Meissner's corpuscles (MC) in CIPN patients before and after use of topical capsaicin (optional). * To assess pain tumor related neuropathy assessment scale (TNAS) before and after topical capsaicin * To assess pain interference using the Brief Pain Inventory (BPI), before and after topical capsaicin * To assess Patient Global Impression of Change (PGIC) * To assess the rate of adverse events and tolerability of topical capsaicin as reported by participants

Conditions

• Peripheral Neuropathy Due to Chemotherapy

Interventions

Type	Name	Description
DRUG	Qutenza Patch	Given topical

Timeline

• Start date: 2025-12-11
• Primary completion: 2027-11-30
• Completion: 2027-11-30
• First posted: 2024-12-20
• Last updated: 2026-01-05

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study