NCT06743750

Comparison Between Different Sampling Sites for Detection of Respiratory Viruses

Comparison Between Nasopharynx and Orobuccal/Nasal Swabs or Saliva for Detection of Respiratory Viruses (ORASAMP)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 501 (actual)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 0 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to validate the use of less invasive samples (saliva, orobuccal or nasal swabs) than nasopharyngeal swab for testing common and clinically relevant respiratory viruses in children and adults presenting to an emergency departements with symptoms compatible with respiratory tract infection. The main question it aims to answer is: \- Is the precision of reverse transcription polymerase chain reaction (RT-PCR) for Influenzavirus A or B, respiratory syncytial virus (RSV), and Rhinovirus, on saliva, orobuccal swabs and nasal swabs comparable to the gold standard nasopharyngeal swab in a pediatric and adult population presenting with symptoms compatible with respiratory tract infection. Among participants the following samples will be collected (nasopharyngeal swab is standard of care and not part of the study samples): * Saliva * Orobuccal swab * Nasal swab

Conditions

• Respiratory Tract Infection Viral

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	RT-PCR in different respiratory tract samples	RT-PCR on saliva, orrobuccal swab and nasal swab will be performed. Nasopharyngeal swab will be performed independently of the study as standard of care.

Timeline

• Start date: 2024-12-19
• Primary completion: 2025-06-20
• Completion: 2025-06-20
• First posted: 2024-12-20
• Last updated: 2025-07-04

Locations

1 site across 1 country: Switzerland