NCT06743269

Improving Sympathetic Activity, Hot Flashes, and Sleep in Midlife Women Using Inspiratory Muscle Strength Training

Time-efficient Inspiratory Muscle Strength Training for Improving Sympathetic Activity, Hot Flashes, and Sleep in Midlife Women

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: Female
• Age: 45 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.

Conditions

• Menopause
• Hot Flashes
• Blood Pressure Regulation

Interventions

Type	Name	Description
BEHAVIORAL	High-Resistance Inspiratory Muscle Strength Training	Performs inspiratory maneuvers at 55% maximal inspiratory pressure (PIMAX) during week 1, 65% PIMAX during week 2, and 75% PIMAX during weeks 3-6.
BEHAVIORAL	Low-Resistance Inspiratory Muscle Strength Training	Performs inspiratory maneuvers at 15% maximal inspiratory pressure (PIMAX) for all 6 weeks.
DEVICE	POWERbreathe K3 device	Inspiratory muscle training device

Timeline

• Start date: 2025-03-27
• Primary completion: 2027-01-01
• Completion: 2027-01-01
• First posted: 2024-12-19
• Last updated: 2026-03-30

Locations

1 site across 1 country: United States