NCT06743243

Effect of Tegoprazan for Elective Surgery Patients Under General Anesthesia

• Status: Enrolling By Invitation
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 174 (estimated)
• Sponsor: Seok Kyeong Oh · Academic / Other
• Sex: All
• Age: 20 Years – 69 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to compare gastric pH right after endotracheal intubation for general anesthesia in patients pretreated with tegoprazan, famotidine, or placebo.

Detailed description

This clinical trial is a prospective, randomized, double-blind, multicenter, investigator-initiated trial that aims to demonstrate the preventive effect of tegoprazan on preoperative aspiration in patients scheduled to undergo surgery using general anesthesia. Subjects who meet the inclusion/exclusion criteria will be randomly assigned to the tegoprazan administration group (Group T), famotidine administration group (Group F), or placebo administration group (Group C) in the same ratio of 1:1:1.

Conditions

• General Anesthesia

Interventions

Type	Name	Description
DRUG	Tegoprazan	Tegoprazan OD tab. 50 mg PO + Saline 20ml IV, one hour before general anesthesia.
DRUG	Famotidine	Famotidine 20mg/10ml+saline 10ml IV + Tegoprazan OD tab. 50 mg placebo PO, one hour before general anesthesia.
DRUG	Placebo	Tegoprazan OD tab. 50 mg placebo PO + Saline 20ml IV, one hour before general anesthesia.

Timeline

• Start date: 2025-07-23
• Primary completion: 2026-10-30
• Completion: 2026-12-30
• First posted: 2024-12-19
• Last updated: 2025-09-05

Locations

1 site across 1 country: South Korea