NCT06743009

Metabolic Effects of the Exercise-metabolite Lac-Phe

The Metabolic Effects of the Exercise-metabolite N-lactoyl-phenylalanine (Lac-Phe)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this double-blinded, randomized cross-over clinical trial is to assess the isolated (i.e. outside the context of exercise) effects of Lac-Phe on appetite and glucose concentrations in healthy volunteers with obesity (BMI 28-35). The main questions it aims to answer are: * Does Lac-Phe reduce appetite in humans? * Does Lac-Phe have glucose-lowering properties in humans? During the study, participants will: * receive an intravenous infusion of Lac-Phe on one study day and a NaCl infusion on another study day. * drink a standard mixed meal * eat an ad libitum meal test * answer appetite questionnaires * indirect calorimetry * blood samples for hormone and substate analyses

Conditions

• Healthy Overweight/Obese

Interventions

Type	Name	Description
OTHER	N-lactoyl-phenylalanine	Intravenous infusion of N-lactoyl-phenylalanine (Lac-Phe)
OTHER	NaCl	0.9% isotonic NaCl infusion

Timeline

• Start date: 2025-05-13
• Primary completion: 2026-03-10
• Completion: 2026-03-10
• First posted: 2024-12-19
• Last updated: 2026-03-27

Locations

1 site across 1 country: Denmark