NCT06740656

Neuromuscular Complications of MEK Inhibitors: a French Case Series and a Systematic Review of the Literature

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 5 (estimated)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

MEK inhibitors (trametinib, cobimetinib, selumetinib or binimetinib) have been used since 2016 to treat metastatic melanoma, by targeting the MAPK pathway Neuromuscular complications (neuropathy, myasthenia or myositis) have been reported in patients treated with MEK inhibitors. With the growing use of these new oncology therapies, neurologists, oncologists and other clinicians are likely to be increasingly confronted with MEK inhibitor-induced neuropathy, myasthenia or myositis. Yet, so far, these complications have only been documented in a few single case reports. Our aim was to characterize the neuromuscular complications associated with MEK inhibitors used either alone or in combination.

Conditions

• Myositis
• Myasthaenia Gravis
• Neuropathy
• Guillain Barré Syndrome
• Parsonage Turner Syndrome

Interventions

Type	Name	Description
OTHER	No Interventions	no intervention

Timeline

• Start date: 2025-03-01
• Primary completion: 2026-01-01
• Completion: 2026-01-01
• First posted: 2024-12-18
• Last updated: 2025-02-18

Locations

1 site across 1 country: France