NCT06740136

Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)

Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS) / Déterminants Génétiques Des Dommages Musculaires Induits Par L'exercice (POLYGENDOMUS)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Lille University · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.

Detailed description

Elite-level sports expose athletes to training loads designed to induce muscle damage, aiming to achieve optimal physiological adaptations. However, the repetitive nature of such damage increases the risk of injury. The ability to assess an athlete's susceptibility to fragility is therefore crucial for optimizing their training and performance. Genetic factors appear to play a significant role in the occurrence of these injuries, particularly through subtle variations in DNA sequences. Depending on the location of these variations within a gene, they may or may not alter the expression or function of the associated protein. The investigators aimed to investigate the relationship between genetic polymorphisms and biological parameters in the context of exercise-induced muscle damage.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Exercise	Muscle induced-damage eccentric exercise

Timeline

• Start date: 2023-03-13
• Primary completion: 2024-06-28
• Completion: 2025-12-19
• First posted: 2024-12-18
• Last updated: 2024-12-18

Locations

1 site across 1 country: France