NCT06739382

Management of Ventilation Acquired Pneumonia Caused by Pseudomonas and Acinetobacter Organisms in a Pediatric Center

Management of Ventilation Acquired Pneumonia Caused by Pseudomonas and Acinetobacter Organisms in a Pediatric Center: a Randomized Controlled Study

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: All
• Age: 1 Month – 12 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to determine the most effective empirical therapy of antibiotics for better ventilator-associated pneumonia control. The main question it aims to answer is: • Which is better for clinical response single or combination empiric antibiotic therapies ?

Conditions

• Ventilation Acquired Pneumonia

Interventions

Type	Name	Description
COMBINATION_PRODUCT	extended meropenem infusion in combination with other options such as Polymyxin, Tigecycline, Ertapenem, or Amikacin.	In the case of XDR or PDR Pseudomonas spp. or Acinetobacter spp. isolation from the patient's specimen, treatment was adjusted to extended meropenem infusion in combination with other options such as Polymyxin, Tigecycline, Ertapenem, or Amikacin in group (A) of patients.
COMBINATION_PRODUCT	two β-lactam antibiotics plus a single non-β-lactam antibiotic	In the case of XDR or PDR Pseudomonas spp. or Acinetobacter spp. isolation from the patient's specimen, treatment was adjusted to include two β-lactam antibiotics plus a single non-β-lactam antibiotic, or a combination of double β-lactam antibiotics, with the aim of avoiding aggressive and toxic antibiotics in group (B) of patients
OTHER	Control group received standard therapy	Treatment was adjusted to the second-line empirical antibiotic according to the hospital's local policy.

Timeline

• Start date: 2021-01-01
• Primary completion: 2021-12-01
• Completion: 2022-01-01
• First posted: 2024-12-18
• Last updated: 2024-12-18

Locations

1 site across 1 country: Egypt

Regulatory

• FDA-regulated drug study