NCT06733376

Evaluating Evidenced Based Options for PTSD Treatment

Evaluating Evidence Based Options for Initial PTSD Treatment Non-Responders

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 400 (estimated)
• Sponsor: Rush University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will look at: How practical it is to offer another round of proven therapy. How effective different therapy options are for people who didn't respond to the first treatment. The goal is to improve personalized care by: Identifying factors that might predict how someone will respond to a second treatment. Creating a simple tool to spot people who might not respond to treatment early, so they can start a different option sooner. The findings will help improve PTSD care by offering better follow-up treatments and matching patients with the approach that works best for them.

Conditions

• PTSD - Post Traumatic Stress Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Cognitive Processing Therapy	Cognitive Processing Therapy is a first-line intervention for the treatment of PTSD that focuses on changing unhelpful patterns of thinking.
BEHAVIORAL	Prolonged Exposure	Prolonged Exposure is an evidence-based treatment for PTSD that helps to reduce the intensity of distress by gradually exposing participants to trauma-related memories, feelings, and situations in real life.
BEHAVIORAL	Skills Training for Affective and Interpersonal Regulation	Skills Training for Affective and Interpersonal Regulation (STAIR) is a evidence-based treatment geared towards helping regulate emotional and interpersonal needs of those with PTSD.

Timeline

• Start date: 2025-10-06
• Primary completion: 2029-06-01
• Completion: 2030-06-01
• First posted: 2024-12-13
• Last updated: 2025-10-22

Locations

1 site across 1 country: United States