NCT06731452

Exploring Neurophysiological Markers of Brain Health

Exploring Markers of Brain Health With EEG and TMS: A Pilot Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (estimated)
• Sponsor: The University of Texas at Dallas · Academic / Other
• Sex: All
• Age: 22 Years – 100 Years
• Healthy volunteers: Accepted

Summary

The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been suggested as a promising brain imaging tool for identifying biomarkers of brain health. In this pilot study, study investigators will explore the neurophysiological metrics of brain health with a non-invasive brain imaging technique, alongside behavioral and fMRI metrics collected through another study (NCT04869111).

Detailed description

The Direct Electro-Physiological Imaging medical device (Delphi-MD), developed by QuantalX Neuroscience, combines both TMS and EEG technologies. This is a non-invasive technique that uses magnetic pulses to temporarily stimulate specific brain areas in participants, and the EEG device records brain electrophysiological response to the stimulation. Recruitment for this pilot study will be restricted to participants in the imaging cohort of a separate study, The BrainHealth Project (NCT04869111). As that cohort is already completing behavioral and fMRI metrics, this exploratory study would allow study investigators to examine relevant associations between those metrics with the neurophysiological metrics from the Delphi device. Study participants will complete two in-person sessions with the Delphi-MD device that align with their pre-scheduled imaging appointments.

Conditions

• Healthy Lifestyle
• Health-Related Behavior

Interventions

Type	Name	Description
BEHAVIORAL	Strategic Memory Advanced Reasoning Training teaches meta-cognitive strategies for individuals to apply to their daily lives for improved performance	Online SMART is a curriculum that teaches strategies of how to use the brain better, in such a way that may improve brain health and performance. SMART strives to achieve optimal cognitive function realized by the brain's ability to efficiently manage complex information by abstracting its essential meaning rather than attempting to memorize details, and to prioritize the information in order to attend to the most relevant parts. Stress Solutions extends the SMART principles to relevant domains of stress and resilience.

Timeline

• Start date: 2025-09-03
• Primary completion: 2026-12-31
• Completion: 2027-05-31
• First posted: 2024-12-12
• Last updated: 2025-09-16

Locations

1 site across 1 country: United States