NCT06729385

Blood Proteome Profiling Identifies Biomarkers in Ischemic Stroke

The Blood Proteome Profiling Identifies Biomarkers Associated with Prognosis in Ischemic Stroke Due to Large Artery Atherosclerosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Capital Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Endovascular thrombectomy and intravenous thrombolysis have become key therapeutic approaches for acute ischemic stroke. However, due to time window limitations, many patients are unable to receive reperfusion therapy, and the majority only receive supportive treatment. Ischemic stroke-related complications, including edema and infection, gradually subside after 7 days post-stroke, with the patient's condition generally stabilizing. Endogenous repair mechanisms will play a critical role in the coming months. This study aims to predict prognostic biomarkers for ischemic stroke patients who have not undergone reperfusion therapy, using blood proteomics data. All samples in our study are derived from this experiment. Our goal is to elucidate the molecular mechanisms underlying post-reperfusion prognosis and to provide insights for optimizing stroke treatment strategies.

Conditions

• Stroke

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	The blood Proteome Profiling	Patients who meet the inclusion criteria will undergo fasting blood collection for proteomics analysis upon admission.

Timeline

• Start date: 2024-12-01
• Primary completion: 2025-02-20
• Completion: 2025-02-20
• First posted: 2024-12-11
• Last updated: 2025-02-21

Locations

4 sites across 1 country: China