NCT06726174

Cell Therapy for Corneal Endothelial Cell Dysfunction

Phase I Clinical Trial of Corneal Endothelial Cell Therapy for Corneal Endothelial Cell Dysfunction

• Status: Enrolling By Invitation
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Culture endothelial cells harvested from donor corneal tissue to treat corneal endothelial cell dysfunction. After ex vivo cultivation, the cells will be injected into anterior chamber and endothelial cells will settle down and adhere to the denuded Descemet's membrane. Eventually, they will reconstitute functional corneal endothelium to subside the corneal edema and improve the visual acuity.

Conditions

• Corneal Endothelial Cell Dysfunction

Interventions

Type	Name	Description
DRUG	ECCEC	0.5-1x10\^6 cells/300 uL, intracameral injection.

Timeline

• Start date: 2025-04-25
• Primary completion: 2028-12-31
• Completion: 2028-12-31
• First posted: 2024-12-10
• Last updated: 2025-12-24

Locations

1 site across 1 country: Taiwan