NCT06723197

Efficacy of Different Durations of Dual and Quadruple Regimens for Helicobacter Pylori Eradication

Efficacy of Different Durations of Dual and Quadruple Regimens for Helicobacter Pylori Eradication: a Multicentre, Randomised, Controlled Trial

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 330 (estimated)
• Sponsor: Shandong University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The study aimed to compare the efficacy and safety of dual and quadruple regimens with different durations (7-day, 10-day, 14-day) for the eradication of Helicobacter pylori. Subjects were randomized to receive the intervention and were reviewed by 13C-urea breath test after 6 weeks. The eradication rates, adverse reaction rates and patient adherence were calculated.

Conditions

• HELICOBACTER PYLORI INFECTIONS

Interventions

Type	Name	Description
DRUG	vonoprazan+amoxicillin	Drug combinations for dual regimens：vonoprazan+amoxicillin
OTHER	Duration of eradication regimen: 7-day	Duration of eradication regimen: 7-day
DRUG	vonoprazan+amoxicillin+tetracycline+bismuth	Drug combinations for quadruple regimens: vonoprazan+amoxicillin+tetracycline+bismuth
OTHER	Duration of eradication regimen: 10-day	Duration of eradication regimen: 10-day
OTHER	Duration of eradication regimen: 14-day	Duration of eradication regimen: 14-day

Timeline

• Start date: 2024-12-10
• Primary completion: 2025-10-01
• Completion: 2025-11-30
• First posted: 2024-12-09
• Last updated: 2024-12-11

Locations

1 site across 1 country: China