NCT06717334

A Study of Lung Cancer Screening in People With Unexplained Weight Loss

Enrichment of Lung Cancer Screening Through Unexplained Weight Loss (UWL) to Stage Shift and Improve Survival

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 409 (estimated)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The researchers are doing this study to see if people with unexplained weight loss who have lung cancer screening are more likely to have or develop lung cancer than people without unexplained weight loss. The lung cancer screening will involve use of low-dose computed tomography (LDCT), a CT scan that gives off very low doses of radiation and can make detailed pictures of the lungs to help find tumors. The study researchers will also analyze participants' blood samples to determine if blood testing can be used to help to diagnose lung cancer.

Conditions

• Lung Cancer Screening

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Low Dose CT imaging	at baseline and at Year 1.
OTHER	blood draws	at baseline and at Year 1.
OTHER	screening questionnaire	at baseline and at 1 year after registration.

Timeline

• Start date: 2024-12-02
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2024-12-05
• Last updated: 2026-01-23

Locations

8 sites across 1 country: United States