NCT06711302

Remote Ischemic Conditioning for Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage

Remote Ischemic Conditioning for Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage: a Multi-center, Randomized, Double-blind, Sham-controlled, Parallel-group Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: Beijing Tiantan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Several recent large-scale clinical trials aimed at improving subarachnoid hemorrhage(SAH) outcomes have concluded with negative results, failing to enhance the prognosis for these patients. Consequently, there is an urgent demand for novel treatment strategies and approaches to address the challenges posed by SAH. Remote ischemic conditioning(RIC) has gained considerable attention in the treatment of stroke, particularly ischemic stroke, with numerous studies demonstrating its potential to enhance neurological outcomes compared to conventional treatments alone.RIC for the treatment of SAH is an investigative strategy in its initial stages. The neuroprotective effects of RIC, particularly its potential to preserve cranial nerve function and ameliorate neurological deficits, confer significant value in the treatment of SAH patients. The precise manner in which SAH patients may benefit from RIC treatment, and the mechanisms by which it improves neurological function, remain to be fully understood. Consequently, randomized controlled trials are necessary to validate the efficacy of RIC in this patient population and to delineate the optimal therapeutic protocols for its application. Based on the above discussion, this study aims to explore the efficacy and safety of RIC in the treatment of SAH.

Conditions

• Subarachnoid Hemorrhage
• Cerebrovascular Disorders
• Brain Diseases
• Stroke
• Cardiovascular Diseases
• Vascular Diseases
• Nervous System Diseases

Interventions

Type	Name	Description
DEVICE	Sham RIC	Remote Ischemic Conditioning is given twice a day with 60mmHg pressure.
DEVICE	Remote Ischemic Conditioning treatment instrument	Remote Ischemic Conditioning is given twice a day with 200mmHg pressure.

Timeline

• Start date: 2025-07-01
• Primary completion: 2026-01-01
• Completion: 2026-04-01
• First posted: 2024-12-02
• Last updated: 2025-07-10

Locations

1 site across 1 country: China