Trials / Not Yet Recruiting
Not Yet RecruitingNCT06710496
HISTOLOGICAL RESULTS IN TRANSGENDER INDIVIDUALS ASSIGNED TO FEMALES AT BIRTH UNDERGOING GENDER AFFIRMATION SURGERY AND IN TESTOSTERONE THERAPY
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (estimated)
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The aim of this study is to report histological results of genital organs removed during gender affirmg surgery in transgender people assigned female at birth (AFAB), to increase the knowledge about the long-term effects of gender affirming hormone therapy with testosterone on these organs and to evaluate the incidence of benign and malign gynecological pathology in AFAB transgender people.
Detailed description
This retrospective, observational, single-center study aims to analyze histological data obtained from the analysis of ovaries, fallopian tubes, uterine body, endometrium, and cervix of assigned female at birth (AFAB) transgender individuals who underwent gender affirming surgey (GAS) with hysterectomy and bilateral adnexectomy or hysterectomy alone following the administration of exogenous Testosterone (T). Histological results of the genital organs removed during GAS can provide important information about the effects and safety of loong term T treatment on these organs. Data on this subject is scarce in the literature. For this reason, even today, pathologists have not been able to establish guidelines for describing the histological results obtained from these patients.Furthermore, this analysis will evaluate the incidence of benign and malignant gynecological pathology in AFAB transgender people.
Conditions
- Pregnancy
- Smoking Behavior
- Testosterone Replacement Therapy
- Drugs
- Comorbidities and Coexisting Conditions
- Gynecological Surgery
- Transgender Men
- Gender Affirmation Surgery
- Hormone Replacement Therapy
- Gynecological Disorders
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | analysis of medical records | analysis of medical records of the patients |
Timeline
- Start date
- 2024-12-01
- Primary completion
- 2025-02-01
- Completion
- 2025-12-01
- First posted
- 2024-11-29
- Last updated
- 2024-11-29
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT06710496. Inclusion in this directory is not an endorsement.