NCT06710353

The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery

The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery: A Prospective Randomized Clinical Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 190 (estimated)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 7 Years
• Healthy volunteers: Not accepted

Summary

The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following cardiopulmonary bypass.

Conditions

• Acute Kidney Injury
• Pediatric Cardiac Surgery

Interventions

Type	Name	Description
DRUG	Albumin solution	A 20% albumin solution is administered over one hour starting from the induction of anesthesia, using the following formula: (4.0-preoperative serum albumin (g/dL))×plasma volume (kg×0.65-0.8 dL)
DRUG	Crystalloid solutions	The same volume of crystalloid solution as the administered albumin is infused.

Timeline

• Start date: 2025-01-09
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2024-11-29
• Last updated: 2025-04-23

Locations

1 site across 1 country: South Korea