NCT06709157

Immunocompetent Versus Immunocompromised Tuberculosis (TB) Patients

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 16 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the top 10 causes of mortality worldwide. It is estimated that in 2017, 10 million people were infected with TB, and 1.6 million died from the disease, including 0.3 million people with human immunodeficiency virus (HIV) infection . TB remains the primary killer of HIV-positive individuals. TB incidence is falling at about 2% per year . Airborne transmission of M. tuberculosis typically causes TB infection in both immunocompetent and immunocompromised hosts and the disease is symptomatic and contagious .

Detailed description

TB and HIV infections are strictly linked together. TB is the most common opportunistic infection and causes high morbidity rate among people living with HIV. Because of the decrease in cell-mediated immunity, HIV alters the pathogenesis of TB, thereby expressively increasing the risk of TB in HIV-positive patients and eventually leading to more severe complications and forms of TB.

Conditions

• Tuberculosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	P24 antigens and antibody	estimation of antigens and antibodies to diagnose HIV
DIAGNOSTIC_TEST	zeihl - Nelsen stain	staining sputum from patients with HIV to detect tubercle bacilli
DIAGNOSTIC_TEST	culture on Lowenstein jensen media	spenciem will be inoculated on LJ media and kept for 2-8 weeks, to see small white colonies
DIAGNOSTIC_TEST	Molecular detection of antibiotic resistance	to see the pattern of antibiotic resistance of tubercle bacilli

Timeline

• Start date: 2024-12-10
• Primary completion: 2024-12-20
• Completion: 2025-06-01
• First posted: 2024-11-29
• Last updated: 2024-11-29

Locations

1 site across 1 country: Egypt