NCT06708676

Washed Microbiota Transplantation in Solid Organ Transplantation

Washed Microbiota Transplantation for Postoperative Complications in Solid Organ Transplantation

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: The Second Hospital of Nanjing Medical University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Solid organ transplantation (SOT), an alternative therapy for end-stage diseases, offers increased longevity and better quantity of life. Posttransplant complications such as gastrointestinal symptoms, infection, and graft rejection increase risk with graft failure and death. However, the treatment of abovementioned complications remains unsatisfactory. Gut dysbiosis has been reported in patients with SOT, especially in patients with posttransplant complications. Recipients are more susceptible to gut dysbiosis as long-term use of immunosuppressants, antibiotics and corticosteroids. Restoring gut microbiome may be a promising therapy for posttransplant complications. Washed microbiota transplantation (WMT) is a newly improved methodology of fecal microbiota transplantation based on automatic facilities, washing process and a new delivery routine. In this study, investigators aimed to evaluate the efficacy and safety of WMT for postoperative complications in SOT.

Conditions

• Solid Organ Transplant Complications

Interventions

Type	Name	Description
OTHER	Washed Microbiota Transplantation	Washed microbiota suspension delivered through mild-gut and lower-gut

Timeline

• Start date: 2024-11-20
• Primary completion: 2029-12-31
• Completion: 2030-12-31
• First posted: 2024-11-27
• Last updated: 2024-11-27

Locations

1 site across 1 country: China