NCT06701214

The Clonal Hematopoiesis & Inflammation in Vasculature Registry and Biorepository

Discovering Outcomes in Clonal Hematopoiesis: The Clonal Hematopoiesis and Inflammation in VasculaturE (CHIVE) Registry and Biorepository

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: Vanderbilt-Ingram Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate the association between clonal hematopoiesis and other conditions. Clonal hematopoiesis (CH) refers to the mutations in a person's stem cells which commonly affect people as they get older. These mutations have notably been linked to increased risk of certain cancers as well as increased risk of heart disease.

Detailed description

Objectives: * To develop the CHIVE Registry with CH patients or patients with elevated risk for CH in order to better characterize associated clinical outcomes and co-morbidities in these populations * To improve understanding of cardiovascular phenotypes and risk of patients with known Clonal Hematopoiesis of indeterminate potential (CHIP) or Clonal Cytopenias of undetermined significance (CCUS) * To investigate prognostic significance of CH mutations for the development hematologic malignancies * To generate a CHIVE Biorepository to acquire patient samples to study the natural history of CH, and to make available to CH investigators.

Conditions

• Clonal Hematopoiesis

Interventions

Type	Name	Description
OTHER	Blood collection	Blood will be taken from participants already undergoing blood collection
OTHER	Saliva collection	Undergo saliva collection
OTHER	Bone marrow collection	Bone marrow will be taken from participants already undergoing bone marrow collection

Timeline

• Start date: 2020-10-28
• Primary completion: 2030-11-30
• Completion: 2031-11-30
• First posted: 2024-11-22
• Last updated: 2024-11-22

Locations

1 site across 1 country: United States