NCT06700382

Different Methods of Capecitabine in Patients With Non-PCR After Neoadjuvant Therapy for TNBC

A Cohort Study of Different Methods of Adjuvant Capecitabine Regimens in Patients With Non-PCR After Neoadjuvant Therapy for Triple Negative Breast Cancer

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,166 (estimated)
• Sponsor: Shu Wang · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The survival rate of patients with pathological complete response (pCR) after neoadjuvant therapy was significantly better than that of patients with tumor residue, that is, non-pCR patients. Therefore, studies have confirmed that intensive adjuvant therapy for patients with non-pCR after neoadjuvant chemotherapy can further improve the survival of this population. Previous studies have given capecitabine treatment to such patients as standard. However, it is unknown whether capecitabine intensification still has the same status under the premise that most patients receive immunotherapy at the neoadjuvant stage; Whether there are differences in the efficacy and safety of capecitabine standard 6-8 cycle intensive regimen and capecitabine metronomic chemotherapy are practical problems encountered in clinical practice. This study explored the efficacy and safety of 6-8 cycles of full dose capecitabine intensive therapy compared with 1-year capecitabine metronomic chemotherapy in patients with T2 and above and/or lymph node positive early triple negative breast cancer who still had invasive tumor after neoadjuvant therapy.

Conditions

• Triple Negative Breast Cancer

Interventions

Type	Name	Description
DRUG	capecitabine	different methods of treatment for capecitabine

Timeline

• Start date: 2019-01-01
• Primary completion: 2031-12-31
• Completion: 2031-12-31
• First posted: 2024-11-22
• Last updated: 2024-11-25

Locations

1 site across 1 country: China