NCT06699953

Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain. The investigators also aim to understand how this EEG biomarker is connected to patient perception to drug liking.

Conditions

• Brain Activity Related to Opioid Administration
• Brain Activity Related to Drug Liking

Interventions

Type	Name	Description
OTHER	Observational study in patients receiving fentanyl for surgery	This observational study enrolls patients receiving fentanyl, a drug routinely administered during surgery under general anesthesia. The primary difference in the investigators' research protocol is the inclusion of a 5-minute interval between fentanyl administration and the induction of general anesthesia. Fentanyl will be given in two boluses of 2 mcg/kg (ideal body weight), spaced 2 minutes apart, totaling 4 mcg/kg. If the participant remains conscious, an additional 2 mcg/kg bolus will be administered after 2 minutes. Additionally, participants will complete a drug-liking questionnaire before the first bolus and every 30 seconds until anesthesia induction, rating how much they "liked" the drug on a 0-100 scale.

Timeline

• Start date: 2025-02-04
• Primary completion: 2026-06-30
• Completion: 2026-12-31
• First posted: 2024-11-21
• Last updated: 2025-12-17

Locations

1 site across 1 country: United States