NCT06694155

Whey Protein Ingestion and Glucose Control in Pre- and Post Diabetic Individuals

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Arkansas · Academic / Other
• Sex: All
• Age: 50 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

To examine the effects of twice daily whey protein consumption on blood glucose and insulin in pre-diabetic and diabetic individuals

Detailed description

Protein consumption in the morning has been shown to reduce appetite and caloric intake (19). In addition, premeal whey consumption reduces post prandial blood glucose, reduces gastric emptying rate, and increases peak blood insulin (10). Thus, it is proposed that ingestion of whey protein within 1hr of waking (and prior to breakfast) and 30 minutes prior to dinner will be more effective in suppressing appetite, carbohydrate intake, and glucose AUC. Ingestion upon waking will mitigate the cortisol-induced drive for carbohydrate intake. Ingestion prior to dinner, the most frequently consumed and largest meal in America (20), will reduce food intake, post meal blood glucose, and insulin area under the curve (21). Specific Aims 1. Determine the effect of WP ingestion within 1hr of waking and prior to breakfast, and 30min prior to dinner, on appetite suppression, carbohydrate and caloric intake, and 24hr glucose AUC over 7d in pre-diabetic (A1C 5.7%-6.4%) and diabetic (A1C 6.5%-7.5%) individuals. 2. Determine the effect of WP ingestion within 1hr of waking and 30min prior to dinner on changes in OGTT, Matsuda index, and whole-body protein balance (compared to control) before and after 7d of WP consumption in pre-diabetic and diabetic individuals. 3. Determine outcome differences between pre-diabetic and diabetic individuals.

Conditions

• Prediabetes / Type 2 Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Whey Protein Isolate Crossover	This crossover intervention includes 1 week of whey protein isolate supplementation and 1 week of placebo supplementation.
DIETARY_SUPPLEMENT	Placebo	1 week of Non-whey protein Placebo supplement

Timeline

• Start date: 2025-01-15
• Primary completion: 2026-11-01
• Completion: 2027-03-01
• First posted: 2024-11-19
• Last updated: 2026-04-06

Locations

1 site across 1 country: United States