NCT06691503

A Clinical Trial of Esophagectomy for Esophageal Carcinoma

A Phase II Clinical Trial of Mediastinoscopic-assisted Transhiatal Laparoscopic Esophagectomy for Early-stage Thoracic Esophageal Squamous Cell Carcinoma

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Brief Summary The pathological type of esophageal cancer (EC) in most patients in East Asia is esophageal squamous cell carcinoma (ESCC). Surgery is the primary treatment for EC. This study compared the feasibility and safety of mediastinoscopic-assisted transhiatal laparoscopic esophagectomy (MATLE) with video-assisted thoracoscopic esophagectomy (VATE). Thirty-five eligible patients with ESCC were assigned to the MATLE group, while seventy matched patients were assigned to the VATE group. The study compared perioperative outcomes and lymph node dissection between the two groups. Additionally, the Kaplan-Meier method was employed to estimate Disease-Free Survival (DFS) and Overall Survival (OS).

Conditions

• Esophageal Squamous Cell Carcinoma

Interventions

Type	Name	Description
PROCEDURE	mediastinoscopic-assisted transhiatal laparoscopic esophagectomy (MATLE)	mediastinoscopic-assisted transhiatal laparoscopic esophagectomy (MATLE)

Timeline

• Start date: 2021-03-01
• Primary completion: 2023-09-01
• Completion: 2024-11-01
• First posted: 2024-11-15
• Last updated: 2024-11-15

Locations

1 site across 1 country: China