NCT06687993

Acetylcholinesterase Inhibitor in Anorexia Nervosa: Multicenter, Double-Blind, Placebo-Controlled Trial

Acetylcholinesterase Inhibitor Treatment in Anorexia Nervosa: a Multicenter, Double-Blind, Placebo-Controlled Randomized Trial

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 147 (estimated)
• Sponsor: Centre Hospitalier St Anne · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if the daily take of donepezil can treat adult patient suffering from anorexia nervosa. The main question it aims to answer is : do daily donepezil intake permit weight gain and reduction of food restriction rituals ? The treatment is a capsule comprising a drug limiting the degradation of a neurotransmitter called acetylcholine. This treatment has long been used to treat certain cognitive disorders. Researchers will compare two drug dosage and a look-alike capsule that contains no drug to see if the dose has an impact on the effect. Participants will take one capsule per day for three months will have regular hospital visits for cognitive and metabolic tests.

Conditions

• Anorexia Nervosa Restricting Type

Interventions

Type	Name	Description
DRUG	Donepezil 2.5 mg	2.5 mg daily oral intake for 90 days
DRUG	Donepezil 5 mg	5 mg daily oral intake for 90 days
DRUG	Placebo Comparator	daily oral intake for 90 days

Timeline

• Start date: 2024-11-01
• Primary completion: 2030-02-01
• Completion: 2030-05-01
• First posted: 2024-11-14
• Last updated: 2024-11-14