NCT06686888

The Impact of Short-Chain Fatty Acids on Gut Hormone Release After Delivery in the Small and Large Intestine of Healthy Volunteers

The Impact of Short-Chain Fatty Acids on the Gut Hormone Release After Delivery in the Small Intestine and Colon

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The goal of this crossover study is to evaluate the impact of short-chain fatty acids (SCFA) on the gut hormone release after administration in the small intestine or colon in healthy participants. The main question it aims to answer is whether the site of administration of SCFA affects the gut hormone release. On test days participants will ingest capsules filled with SCFA that are specifically delivered in the small intestine or the colon. Subsequently, blood samples are collected at regular time points.

Conditions

• Satiety Hormones
• Short-chain Fatty Acids
• Satiety and Appetite
• Intestinal Absorption
• Metabolism
• Glucose Homeostasis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	SCFA	On test days participants will ingest the capsules during a standard no fiber breakfast. Blood samples will be collected at regular time points for 8 hours. A visual analogue scale that questions hunger and satiety will be completed at regular time points.
DIETARY_SUPPLEMENT	microcristalline cellulose	On test days participants will ingest the capsules during a standard no fiber breakfast. Blood samples will be collected at regular time points for 8 hours. A visual analogue scale that questions hunger and satiety will be completed at regular time points.

Timeline

• Start date: 2024-09-25
• Primary completion: 2024-12-20
• Completion: 2024-12-20
• First posted: 2024-11-13
• Last updated: 2026-02-23

Locations

1 site across 1 country: Belgium