NCT06686173

Effect of Donor Chose on the Outcomes of GVHD Prophylaxis Underwent the Combined Treatment of ATG/PTCy for Haplo-HSCT

The Effect of the Parous Female and Young Male Donor on the Outcomes of GVHD Prophylaxis Underwent the Combined Treatment of ATG and PTCy for Haplo-HSCT: a Prospective, Multi-center, Cohort Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 114 (estimated)
• Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective, multicenter, cohort study. The high-risk, relapse and refractory AML patients were enrolled in this study. And the goal of this study is to study the effect of the parous female donor and young male donor on the outcomes of graft-versus-host disease (GVHD) prophylaxis underwent the combination of ATG and PTCy for haploidentical peripheral blood stem cell transplantation

Conditions

• High-Risk Acute Myeloid Leukemia
• Relapse And/or Refractory AML

Interventions

Type	Name	Description
OTHER	None-placebo	This is one kind descriptive study. The different donor groups made the cohorts different: the parous female donor and young male donor
OTHER	non-intervention study	This study is one kind of non intervention study
OTHER	donor selection	the intervention of this study was the different donor groups: the parous female donor and young male donor. All the patients involved in this study were treated by the combination of ATG and PTCy

Timeline

• Start date: 2025-02-01
• Primary completion: 2027-02-01
• Completion: 2028-02-01
• First posted: 2024-11-13
• Last updated: 2025-01-07