NCT06685913

The Effect of Ketone Esters on Forearm Glucose Metabolism

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (estimated)
• Sponsor: University of Exeter · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important tool for treating disease or recovering from exercise. The purpose of this research is to determine if a ketone drink can increase sugar uptake in our muscles. This research will provide new knowledge about the regulation of blood sugar.

Detailed description

Impaired skeletal muscle glucose uptake following a meal ("insulin resistance"), is a primary risk factor for developing type 2 diabetes. We and others have consistently shown that ingesting exogenous ketones can reduce blood glucose concentration. Mechanistically, this must arise through reduced glucose release (i.e. from liver), and/or increased uptake (i.e. into skeletal muscle). Our current MRC-funded work is focussing on ketone-liver interactions in patients with type 2 diabetes. Here we aim to investigate how KE influence skeletal muscle glucose metabolism.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone supplement	100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com) consumed 30 min prior to a mixed meal tolerance test
DIETARY_SUPPLEMENT	Placebo supplement	Placebo with bitter agent to flavour match, consumed 30 min prior to a mixed meal tolerance test

Timeline

• Start date: 2024-11-11
• Primary completion: 2025-12-31
• Completion: 2034-12-31
• First posted: 2024-11-13
• Last updated: 2025-01-22

Locations

1 site across 1 country: United Kingdom