NCT06682858

Developing a Novel Therapy for Aversive Sensory Experiences in Autism

Developing a Mechanistically Informed Therapy for Aversive Sensory Experiences With Autistic Youth

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 11 Years – 16 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to assess whether a new psychological treatment can lead to changes in sensory experiences in autistic young people. Participants will complete a group intervention designed to help manage sensory difficulties and associated anxiety. Participants will also complete tasks before and after the intervention to assess whether the treatment can lead to changes in brain and behavioural responses to sensory experiences. The main questions the study aims to answer are: 1. Does the intervention improve sensory difficulties and associated anxiety in autistic young people? 2. Does the intervention change brain and biological responses to sensory experiences in autistic young people? Researchers will also collect feedback from participants to help improve the design and delivery of the treatment in future studies.

Detailed description

The purpose of this study is to pilot a group-based cognitive behavioural therapy (CBT) intervention focused on managing sensory differences associated with autism. Another aim of this study is to test whether the intervention can modulate perceptual and neurophysiological markers (e.g. via electrocephalogram \[EEG\], heart rate and skin conductance) of sensory processing in autistic children and adolescents. A final aim will be to collect qualitative feedback from autistic young people with the aim of refining and improving the intervention for larger studies in the future. The main aims of the study are: 1. To assess the feasibility of a novel CBT intervention for the management of sensory difficulties and associated anxiety in autistic youth. 2. To gather proof-of-concept data that the intervention can be used to modulate sensory neurophysiological and perceptual markers. 3. To gather qualitative feedback and PPIE to inform refinements on the design and delivery of the intervention for further studies.

Conditions

• Autism
• Autism in Children

Interventions

Type	Name	Description
BEHAVIORAL	Group Cognitive Behavioural Therapy	Participants will complete 8 group sessions of a CBT-based intervention designed to help self-regulate sensory difficulties in autistic young people

Timeline

• Start date: 2024-11-29
• Primary completion: 2025-12-11
• Completion: 2025-12-11
• First posted: 2024-11-12
• Last updated: 2026-04-15

Locations

1 site across 1 country: United Kingdom