NCT06682039

Attention Bias Modification for the Improvement of Anxiety in Adolescent and Young Adult Cancer Survivors

Anxiety and Negative Attentional Bias in Adolescent and Young Adult Cancer Survivors

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Fred Hutchinson Cancer Center · Academic / Other
• Sex: All
• Age: 15 Years – 29 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial studies how well attention bias modification (ABM) improves anxiety in adolescent and young adult (AYA) cancer survivors. Cancer-related anxiety is the most prevalent mental health problem affecting AYA cancer survivors. Cancer-related anxiety is associated with long-term negative outcomes such as poor quality of life, depression, distress, substance use, sleep problems, fatigue, and pain. ABM uses techniques to help patients change the way they react to environmental triggers that may cause a negative reaction. ABM uses brief self-guided smartphone applications. Patients complete repetitive association reaction-time tasks targeting automatic and unconscious negative attention biases to retrain attention away from perceived threat and towards a neutral or positive stimuli. Gratitude-finding and savoring activities are also provided to maintain and increase positive emotions. Using ABM plus gratitude-finding and savoring activities may improve anxiety in AYA cancer survivors.

Detailed description

OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients engage in ABM over 10 minutes twice a week (BIW) and respond daily to text messaging prompts activity for 4 weeks. ARM II: Patients engage in inert attention task sessions over 10 minutes BIW for 4 weeks. Patients also receive and respond to text messaging prompts QD for 4 weeks. After completion of study intervention, patients are followed up at 4 weeks. After completion of this 4 week follow up survey, patients are given access to all components of ABM and texts on study.

Conditions

• Childhood Hematopoietic and Lymphatic System Neoplasm
• Childhood Malignant Solid Neoplasm

Interventions

Type	Name	Description
OTHER	Internet-Based Intervention	Engage in ABM + text messaging prompts
OTHER	Internet-Based Intervention	Engage in inert attention task sessions
OTHER	Interview	Ancillary studies
OTHER	Questionnaire Administration	Ancillary studies
OTHER	Text Message-Based Navigation Intervention	Participants will respond to daily messaging prompts.

Timeline

• Start date: 2024-11-08
• Primary completion: 2026-01-12
• Completion: 2026-01-12
• First posted: 2024-11-12
• Last updated: 2026-01-30

Locations

1 site across 1 country: United States