NCT06681935

Defining Mechanisms of Surgical Site Infection After Oral Cancer Surgery

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Medical College of Wisconsin · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

The study design is an observational cohort study of patients undergoing standard of care oral cavity reconstruction. An observational study is required to prospectively evaluate microbial and antibiotic mechanisms underlying surgical site infection after oral cavity reconstruction.

Detailed description

This is a single institution study at the Medical College of Wisconsin, given the feasibility of projected sample size accrual as well as the clinical and translational expertise at this location for investigating surgical site infection after oral cavity reconstruction. Biospecimens collected will include oral, nasal, pharyngoesophageal, and skin microbial swabs, blood, and discard tissue samples obtained during standard of care oral cavity reconstruction surgery and an oral swab and nasal swab obtained post-operatively.

Conditions

• Oral Cancer

Interventions

Type	Name	Description
PROCEDURE	Oral Cavity Reconstruction	This procedure includes a planned surgical connection from the oral cavity to the neck soft tissues which is repaired through free or pedicled flap reconstruction.

Timeline

• Start date: 2025-04-29
• Primary completion: 2027-05-01
• Completion: 2027-05-01
• First posted: 2024-11-12
• Last updated: 2025-05-21

Locations

1 site across 1 country: United States