NCT06681194

Silver Nitrate vs. Triamcinolone for Treatment of Hypergranulation Tissue

A Comparative Study of Silver Nitrate, Triamcinolone, and Their Successive Combined Use on Hypergranulation Tissue in Traumatic Wounds: A Randomized Control Trial

• Status: Not Yet Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 270 (estimated)
• Sponsor: Francesco Egro · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This randomized controlled trial aims to compare the efficacy of silver nitrate, triamcinolone, and a successive use of both treatments in managing hypergranulation tissue in traumatic wounds. Conducted over a four-year period at UPMC Mercy, the study will involve patients presenting with hypergranulation tissue. Participants will be randomly assigned to receive either topical silver nitrate, topical triamcinolone, or a combination of the two in succession. The study will assess treatment outcomes based on the reduction or resolution of hypergranulation tissue, with the goal of identifying the most effective therapeutic approach. This research will provide valuable insights into optimizing treatment strategies for hypergranulation tissue in traumatic wounds.

Conditions

• Wound Healing
• Granulation Tissue

Interventions

Type	Name	Description
DRUG	Silver Nitrate	See "Silver nitrate only" study arm
DRUG	triamcinolone	See "Triamcinolone only" study arm
DRUG	Silver nitrate + triamcinolone	See "Combination group" study arm

Timeline

• Start date: 2025-06-01
• Primary completion: 2028-12-31
• Completion: 2028-12-31
• First posted: 2024-11-08
• Last updated: 2025-03-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study