NCT06671756

Metabolic Effects of Fructose Intake

The Metabolic Response to Fructose Ingestion

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Baylor College of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 64 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to learn how fructose ingestion affects metabolic factors in healthy adults aged 18-64, with a BMI between 19 and 30 kg/m², of any sex or gender. Specifically, the study aims to examine the impact of fructose compared to glucose on circulating metabolic factors including the soluble leptin receptor. The main questions it aims to answer are: How does fructose ingestion influence levels of circulating metabolic markers, including the soluble leptin receptor? Does fructose consumption have different metabolic effects compared to glucose? Participants will: Complete a screening phone call to review their health history and eligibility. Attend two in-person visits at least two weeks apart, where they will: Fast for 8 hours beforehand. Consume a beverage containing either 75g of fructose or glucose. Have blood drawn at regular intervals for up to 5 hours after consumption to measure circulating levels of metabolic markers.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Fructose Ingestion	Participants will consume a beverage containing 75g of fructose dissolved in 225ml of water.
DIETARY_SUPPLEMENT	Glucose Ingestion	Participants will consume a beverage containing 75g of glucose dissolved in 225ml of water.

Timeline

• Start date: 2024-12-02
• Primary completion: 2025-04-30
• Completion: 2025-05-31
• First posted: 2024-11-04
• Last updated: 2025-07-24

Locations

1 site across 1 country: United States