NCT06670820

iTBS in MCI and Mild AD

The Effects of Intermittent Theta-burst Stimulation on Cognitive Function in Patients With Mild Cognitive Impairment and Mild Alzheimer's Disease and the Role of Brain-Derived Neurotrophic Factor

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: National Defense Medical Center, Taiwan · Academic / Other
• Sex: All
• Age: 50 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.

Conditions

• Mild Cognitive Impairment (MCI)
• Mild Alzheimer Disease

Interventions

Type	Name	Description
DEVICE	Active rTMS	iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total10 sessions
DEVICE	Sham rTMS	sham iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total 10 sessions

Timeline

• Start date: 2024-10-31
• Primary completion: 2028-12-31
• Completion: 2028-12-31
• First posted: 2024-11-01
• Last updated: 2024-11-01

Locations

1 site across 1 country: Taiwan