NCT06668974

Causal Associations Between Allergic Rhinitis and Asthma

Bidirectional Mendelian Randomization Study Reveals Causal Associations Between Allergic Rhinitis and Asthma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 239,607 (actual)
• Sponsor: Zhibin Xu · Academic / Other
• Sex: All
• Age: 0 Years
• Healthy volunteers: —

Summary

This study investigates the causal relationship between allergic rhinitis and asthma using a bidirectional two-sample Mendelian randomization approach. Genetic data were derived from UK Biobank for allergic rhinitis and from Finnish biobank for asthma. This analysis aims to clarify the potential causal link between these two conditions.

Detailed description

This observational study utilizes a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal association between allergic rhinitis and asthma. The genetic data for allergic rhinitis were obtained from the UK Biobank, encompassing 18,934 cases and 64,595 controls, while asthma data were derived from a Finnish biobank, including 20,629 cases and 135,449 controls. The Mendelian randomization analysis was performed using inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods to ensure robust causal inference. Additional tests, such as Cochrane's Q test and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), were applied to assess heterogeneity and pleiotropy, enhancing the reliability of the findings. The results are expected to provide insights into the bidirectional causal relationship between allergic rhinitis and asthma, potentially informing future prevention and treatment strategies.

Conditions

• Allergic Rhinitis
• Asthma

Interventions

Type	Name	Description
OTHER	Mendelian Randomization	This study utilizes a bidirectional Mendelian randomization approach to analyze genetic data from individuals with allergic rhinitis and asthma. No active intervention is applied; genetic variants serve as instrumental variables to assess causal associations between the conditions.

Timeline

• Start date: 2024-10-01
• Primary completion: 2024-10-15
• Completion: 2024-10-28
• First posted: 2024-11-01
• Last updated: 2024-11-01

Locations

1 site across 1 country: China