NCT06665945

The SENTRY Study: Testing Whether Changes in Platelet RNA Enhance the Early Diagnosis of Ovarian Cancer

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 245 (estimated)
• Sponsor: University of Utah · Academic / Other
• Sex: Female
• Age: 21 Years
• Healthy volunteers: Accepted

Summary

The purpose of the SENTRY (Stability Enhanced Transcriptional Analytics) Study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses ovarian cancer. Using retrospective data, the investigators have developed an approach that appears to accurately classify ovarian cancer with relatively high sensitivity and specificity. The SENTRY Study will build upon these retrospective analyses to prospectively recruit women with ovarian cancer or an ovarian mass (and healthy control women), obtain platelet RNA samples from whole blood, and perform validation analyses to test our hypothesis.

Conditions

• Ovarian Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Platelet RNA expression	The SENTRY (Stability Enhanced Transcriptional Analytics) Study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses ovarian cancer.

Timeline

• Start date: 2025-04-15
• Primary completion: 2027-12-01
• Completion: 2027-12-01
• First posted: 2024-10-30
• Last updated: 2026-04-09

Locations

1 site across 1 country: United States