NCT06664515

Changes InMPOD After Full-thickness Macular Hole Closure

Changes in Macular Pigment Optical Density After Full-thickness Macular Hole Closure Using Inverted Flap Technique

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 15 (actual)
• Sponsor: Federico II University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The notable increase in MPOD following successful surgery suggests its potential role as a valuable adjunctive biomarker associated with a good visual prognosis following this type of macular hole surgical interventions.

Detailed description

Full-thickness macular hole (FTMH) is a debilitating retinal disorder, particularly in its advanced forms, necessitating surgical intervention for vision restoration. This study showes the successful closure of a large FTMH using the inverted flap technique, highlighting the essential role of multimodal imaging, and particularly of macular pigment optical density (MPOD) assessment, in preoperative and postoperative evaluation. Surgery was performed by an expert vitreoretinal surgeon, resulting in significant postoperative improvements in visual acuity and retinal architecture. Multimodal imaging, including MPOD assessment, played a pivotal role in preoperative evaluation and postoperative monitoring.

Conditions

• Full Macular Hole

Interventions

Type	Name	Description
PROCEDURE	Ciro Costagliola	invert flap tecnique

Timeline

• Start date: 2023-06-01
• Primary completion: 2023-07-01
• Completion: 2024-10-01
• First posted: 2024-10-29
• Last updated: 2024-11-01

Locations

1 site across 1 country: Italy