NCT06659458

Utilizing Long-read Sequencing to Investigate the EGFR Landscape of EGFR Positive Lung Cancer Patients

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Our Lady of the Lake Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

EGFR gene mutations are some of the most commonly occurring mutations in non-small cell lung cancer. Investigators have developed a DNA instability model that estimates a risk score to assess the likelihood of an individual acquiring a cancer-linked mutation. The aim of this study is to collect blood from both those diagnosed with EGFR positive lung cancer and healthy individuals, evaluate their gene sequence surrounding the EGFR landscape and use the cancer positive and healthy sequences to validate the risk assessment model, which may one day be used to provide insight on susceptibility of getting EGFR positive lung cancer or potentially other cancer types.

Conditions

• Lung Cancer - Non Small Cell
• EGFR Exon 19 Deletion Mutation

Interventions

Type	Name	Description
OTHER	blood draw	A 10ml Blood sample will be taken and used to sequence the EGFR gene and surrounding DNA.
OTHER	Gene sequencing	Subjects will have their DNA sequenced within and around the EGFR gene.

Timeline

• Start date: 2025-01-01
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2024-10-26
• Last updated: 2025-03-20

Locations

1 site across 1 country: United States