NCT06652932

Acute Effects of Low Temperature Exposure on Respiratory System

Acute Effects of Low Temperature Exposure on Respiratory Health in Healthy Young Adults: A Randomized Controlled Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Fudan University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low-temperature exposure on respiratory health and the underlying mechanisms.

Detailed description

The investigators will conduct a randomized controlled human exposure crossover study among about 40 healthy young adults in Shanghai, China. Each subject will be exposed twice: once to the low temperature (15℃) and once to the moderate temperature (22℃) in a chamber for about 2 hours. During the exposure session, each subject will be requested to rest. Health examinations will be conducted immediately prior to exposure, during the period of exposure, and after exposure. Health examinations include lung function tests and exhaled breath test. Investigators plan to collect blood, pharyngeal secretion, exhaled breath condensate and urine samples.

Conditions

• Lung Function

Interventions

Type	Name	Description
OTHER	Low temperature (15°C) group	The exposure group will be exposed to low temperature (15°C) in a chamber for about 2 hours, resting during the whole periods.
OTHER	Moderate temperature (22°C) group	The exposure group will be exposed to thermoneutral temperature (22°C) in a chamber for about 2 hours, resting during the whole periods.

Timeline

• Start date: 2024-10-16
• Primary completion: 2024-11-16
• Completion: 2026-12-31
• First posted: 2024-10-22
• Last updated: 2025-02-27

Locations

1 site across 1 country: China