NCT06651112

The ATP Project (Antipsychotic-TEP-Psychosis)

Impacts of Psychosis and Antipsychotics on Cerebral Energy Metabolism: the ATP Project (Antipsychotic-TEP-Psychosis)

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 18 (estimated)
• Sponsor: Université de Sherbrooke · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to the early impacts of psychosis and antipsychotic medications on brain metabolism in young adults recently diagnosed with a first episode of psychosis. The main question aims to evaluate the effect of 4 to 6 weeks of antipsychotic medication on brain metabolism measured by PET scan (cerebral uptake of 11C-Acetoacetate + 18 Fluorodeoxyglucose). Participants will undergo a multimodal imaging protocol with other measures of psychopathology (e.g., cognition, depressive symptoms, etc.) and (metabolic marker, inflammation, etc).

Conditions

• First Episose Psychosis
• Metabolic Disease
• Psychosis; Episode

Interventions

Type	Name	Description
DRUG	Antipsychotic drugs	Any Antipsychotic drugs prescripbe as standrd of care for this specific populaton

Timeline

• Start date: 2024-11-01
• Primary completion: 2026-11-01
• Completion: 2027-06-01
• First posted: 2024-10-21
• Last updated: 2024-11-08

Locations

1 site across 1 country: Canada